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OJBTM
Online
Journal of Bioinformatics©
Volume 13(1):33-40, 2012
Model
and molecular
docking substrate stabilization of Microsporum
canis keratinase
MVK
Karthik, Hanan
Syed, Tridisha
Goswami, Pratyoosh
Shukla
Birla Institute of Technology (Deemed University), Mesra,
Ranchi-835215, Jharkhand, India.
ABSTRACT
Karthik
MVK, Syed H, Goswami T, Shukla
P., Model and molecular docking substrate
stabilization of Microsporum canis
keratinase, Online J Bioinform,
13(1):33-40,
2012.
Keratinophilic
fungi
vigorously degrade keratin. Keratinase of Microsporum canis
was modeled
with an accuracy RMS Z score of
1.432 using PROVE
software. Molecular
docking between modeled keratinases
from species of keratinophilic
fungi viz. Microsporum
canis with
different types of keratins as substrates was performed with
scores of -451.89 kj/mol
and -262.37 kj/mol, respectively.
Arg1031 is conserved in keratinase
while interacting with both keratins
Key
words:
Keratinophilic fungi, keratin, keratinase, Microsporum
canis, molecular docking.