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Online Journal of Veterinary Research©

Volume 22 (1):38-50, 2018.

Micro RNA cellular signaling pathways for mastitis in dairy cows


1Zahra Beyranvand, 2Ziaaldin Mirhosseini, 3*Mostafa Ghaderi-Zefrehei, 4Arash Fazeil, 5Seyed Hossein Hosseini Moghadam,6Kianoush Zarrin Kavyani



1PhD student, Guilan University, Rasht, 2Professor in molecular genetics, Guilan University, Rasht, 3Assistant Professor in systems biology, Yasouj University, Yasouj, 4Assistant professor in molecular genetics, Ilam University, Ilam, 5Associate Professor in molecular genetics, Guilan University, Rasht, 6Faculty member Ilam University, Ilam, Iran. *Corresponding author: Mostafa Ghaderi-Zefrehei. Email:




Beyranvand Z, Mirhosseini Z, Ghaderi-Zefrehei M, Fazeil A, Hosseini Moghadam SH,  Kavyani KZ., Micro RNA cellular signaling pathways for mastitis in dairy cows, Onl J Vet Res., 22 (1):38-50, 2018. Epigenetics may affect signaling pathways for mastitis in dairy cattle. In recent years, the use of microRNA’s as biomarkers has been widespread for treatment of disease. We extracted micro-RNA’s  bta-mir’s-146a, -223, -21-5p, -181 and -16a and predicted target genes with Mirtarbase and Targetscan databases. Target gene mammary gland tissue expression was extracted from NCBI database. With DAVID software, signaling pathways were identified in KEGG.  We found bta-mir-146a affected 7 proteins, -223, 11 proteins and 21-5p 9 proteins involved in cellular signaling pathways in mastitis. Micro-RNA’s b-mir-181 and -16a may affect signaling pathways for Prolactin, TLR, TNF Progesterone and Estrogen molecular markers. In this study, we found that the microRNAs examined revealed pathways that could be drug targets and/or genes for breeding to reduce incidence of mastitis.


KEY WORDS: Bioinformatics, microRNAs, Signaling Pathways, Mastitis, KEGG.