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Online Journal of Veterinary Research©
Volume 22 (9):824-831, 2018.
Effect of non-steroidal anti-inflammatory drugs on bone marrow stem cells in male Albino mice.
Ahlam Hameed Mageed and Muthana Ibrahim Maleek.
Department of Biology, College of Sciences, University of Wasit, Iraq.
Mageed AH, Maleek MI., Effect of non-steroidal anti-inflammatory drugs on bone marrow stem cells in male Albino mice, Onl J Vet Res., 22 (9):824-831, 2018. NSAIDS may generate free radicals which could damage genetic material. Groups of 10 mice each were injected intraperitoneal non-steroidal anti-inflammatory (NSAIDS) alone or in combinations, once and sacrificed 24h later for evaluation of bone marrow chromosomal aberrations (CA), and micronuclei (MN). We examined 5000 stem cells from each group of 10 mice. Control cells had 2.2-2.4% MN and 13-13.8% CA. Results showed that mice given 30mg Diclofenac, 3mg Meloxicam, 5mg Ketoprofen, 30mg Ibuprofen or 0.3mg/kg Piroxicam had increased CA (~20-32%) and MN (3.8-4.5%) whereas in those injected 30mg/kg Naproxen we found no significant increase. However, when combined with 30mg iboprufen, 30mg/kg naproxen did increase CA and MN. Combinations of 5mg Ketoprofen with 0.3mg/kg Piroxicam 0.3mg/kg or Meloxicam 3mg/kg + Diclofenac 30mg/kg enhanced MN (6.0-6.3%) and CA (41-41.6%) compared with single NSAIDS or controls. This may have been an additive and/or synergistic effect.
Key words: Non-steroidal anti-inflammatory drugs, chromosomal aberrations, micronuclei, mice bone marrow, stem cells, micronuclei, chromosomal abberations.