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 OJVRTM

Online Journal of Veterinary Research © 

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume  28 (3): 135-139, 2024

Toxicological assessment of oral Metamitron in goats

 

A Nayeka   M Khanb, SK Mannac, AK Chakrabortyd, TK Mandal

 

a,b,d,Department of Veterinary Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences, Kshudiram Bose Sarani,  CCentral Inland Fisheries Research Institute, Barrackpore Kolkata-700120 West Bengal India.

 

ABSTRACT

 

Nayeka A, Khanb M, Mannac SK,.Chakrabortyd AK, Mandal TK., Toxicological assessment of oral Metamitron in Goats, Onl J Vet Res.,  28 (3): 135-139, 2024.  A toxicological assessment was performed in goats following repeated oral administration of metamitron. Groups of 3 black Bengal male adult goats each, were dosed 10ml of 1% carboxy methyl cellulose (controls), levamisole at an immuno-stimulating dose subcutaneously (drug controls) or Metamitron at 30 mg/Kg in 10 ml Carboxy methyl cellulose (treated animals), daily for 35 days. Jugular blood   was taken before administration and every 7 days after treatment.. Metamitron did not alter the immune status but pre-scapular lymph nodes and spleen revealed proliferation of lymphoid follicles with moderate lymphocytosis. The changes did not correlate  with changes in white blood cells.

 

Key word: Metamitron, goat, histopathology, hemogram, immunity.

  

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