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OJVRTM
Online Journal of Veterinary
Research©
Volume 24(11): 659-664, 2020
Toxicological
assessment of oral Metamitron in goats.
A Nayeka, M
Khanb, SK Mannac, AK Chakrabortyd and TK Mandald
a,b,d,Department
of Veterinary Pharmacology and Toxicology, West Bengal University of Animal and
Fishery Sciences, 37 Kshudiram
Bose Sarani, CCentral Inland Fisheries Research Institute, Barrackpore Kolkata-700120 West Bengal India.
ABSTRACT
Nayeka A, Khanb M, Mannac SK, Chakrabortyd AK,
Mandal TK., Toxicological assessment of oral Metamitron
in Goats, Onl J Vet Res., 24(11): 659-664, 2020.
A toxicological assessment was performed
in goats following repeated oral administration of metamitron.
Groups of black Bengal male adult goats were dosed 10ml of 1% carboxy methyl cellulose (controls), injected subcutaneous 2.25mg/kg
levamisole and 30mg metamitron in 10 ml Carboxy methyl cellulose daily for 35 days. Jugular blood was taken before
administration and every 7 days after treatment. Metamitron
did not alter the immune status but pre-scapular lymph nodes and spleen revealed
proliferation of lymphoid follicles with moderate lymphocytosis. The changes
did not correlate with
changes in white blood cells.
Key word: Metamitron, Goat, Histopathology,
Hemogram, Immunity.
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