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OJVRTM

Online Journal of Veterinary Research

 

Volume 24(11): 659-664, 2020


Toxicological assessment of oral Metamitron in goats.

 

A Nayeka, M Khanb, SK Mannac, AK Chakrabortyd and TK Mandald

 

a,b,d,Department of Veterinary Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences, 37 Kshudiram Bose Sarani, CCentral Inland Fisheries Research Institute, Barrackpore Kolkata-700120 West Bengal India.

 

ABSTRACT

 

Nayeka A, Khanb M, Mannac SK, Chakrabortyd AK, Mandal TK., Toxicological assessment of oral Metamitron in Goats, Onl J Vet Res., 24(11): 659-664, 2020. A toxicological assessment was performed in goats following repeated oral administration of metamitron. Groups of black Bengal male adult goats were dosed 10ml of 1% carboxy methyl cellulose (controls), injected subcutaneous 2.25mg/kg levamisole and 30mg metamitron in 10 ml Carboxy methyl cellulose daily for 35 days. Jugular blood was taken before administration and every 7 days after treatment. Metamitron did not alter the immune status but pre-scapular lymph nodes and spleen revealed proliferation of lymphoid follicles with moderate lymphocytosis. The changes did not correlate with changes in white blood cells.

 

Key word: Metamitron, Goat, Histopathology, Hemogram, Immunity.


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