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Online Journal of Veterinary Research©
Volume 22 (7):596-601, 2018.
Effect of gentamycin and calcium EDTA on mesenteric lymph nodes in rabbits
following oral Salmonella typhimurium infection.
Ahmed Sami Jarad1, Zaid Yaseen Ibrahim1, Rafid, K. Ali1, Mustafa Salah Hasan1, Maher Saber Owain2, Mohammed Ali Hussein1
1Department(s) of Internal and Preventive Veterinary Medicine, College(s) of Veterinary Medicine, University of Fallujah, 2University of Tikrit, Iraq.
Jarad AS, Ibrahim ZY, Ali RK, Hasan MS, Owain MS, Hussein MA., Effect of gentamycin and calcium EDTA on mesenteric lymph node of rabbits following Salmonella typhimurium infection, Onl J Vet Res., 22 (7):596-601, 2018. Five groups of 5 mixed breed rabbits each were gavaged 5X109 CFU Salmonella typhimurium with or without 0.05ml/kg gentamicin (5mg/ml) and/or 40mg/kg Ca-EDTA 40mg/kg, 24h post infection. Controls (n=5) were neither challenged nor treated. Necropsies were performed at 48 and 96hrs after appearance of signs. At necropsy, compared with controls, in those challenged with S. typhimurium and/or treated, nodes appeared edematous, soft, hemorrhagic, and enlarged. In rabbits challenged with S. typhimurium only, there was severe lymphocyte depletion and necrosis. In those challenged but given gentamicin only, or EDTA only, there was still lymphocytosis and macrophage infiltration with defined zones of necrosis, Finally in rabbits challenged with S typhimurium, but given both Gentamycin and EDTA, lymph nodes appeared normal macroscopically and microscopically. We find that a single dose of gentamycin with EDTA given 24h after challenge, may prevent mesenteric lymph node pathology induced by S typhymurium in rabbits
Key words: Salmonella, rabbits, Mesenteric lymph nodes, Ca-EDTA, gentamicin.