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OJVRTM
Online
Journal of Veterinary Research©
Volume 17 (5): 286-299, 2013. Extensively Redacted 2017.
Effects of Coenzyme Q10 and Vitamin
E on methyl mercury induced brain lesions in Wistar rats.
Shahbazfar AA PhD,
Mohammadpour R (DVM)
Department of Pathobiology, Faculty of Veterinary Medicine, University
of Tabriz, Iran
ABSTRACT
Shahbazfar AA, Mohammadpour R., Effects of
Coenzyme Q10 and Vitamin E on methyl mercury induced brain lesions in Wistar rats, Onl J Vet Res., 17 (6): 339-338,
2013. Coenzyme Q10
and vitamin E have been shown to ameliorate mercury toxicity. Groups of 6 healthy weaning male Wistar rats
each were given 30ppm methyl mercury (30Me-HG) in drinking water, 30MeHg with
5mg/kg CoQ10 by gavage, 30MeHg with 10mg CoQ 10 and 30MeHg
with 350ppm Vitamin E in a ration. Compared with results in
normal control untreated rats, lesions attributed to mercury in
order of severity occurred in the deep cerebellar nuclei, cerebral cortex, hippocampus,
cerebellum, caudate putamen and corpus collosum. At necropsy, rats given 30MeHg had increased cerebrospinal fluid, meningeal opacity, edema, slight congestion and brain swelling. Histology
revealed edema
in perivascular spaces, neuronal swelling and necrosis, hyperemia, central chromatolysis, neuronophagia,
glial nodule formation, satellitosis, perivascular cuffing with
lymphocytosis and scattered macrophages.
Rats treated with coenzyme
10mg/kg Q10 showed a reduction in neuron necrosis and gliosis in deep cerebellar nuclei
and caudate putamen. In rats given Vitamin E, lesions appeared less
severe but the type of lesions did not change.
KEYWORDS: Coenzyme Q10, Vitamin E, Methyl mercury, Rat brain.