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Online Journal of Veterinary Research©
Volume 26 (6): 429-437, 2022.
Effects of Coenzyme Q10 and Vitamin E on methyl mercury toxicity in brain of Wistar rats.
Shahbazfar AA PhD, Mohammadpour R DVM.
Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Iran
Shahbazfar AA, Mohammadpour R. Effects of Coenzyme Q10 and Vitamin E on methyl mercury toxicity in brain of Wistar rats, Onl J Vet Res., 26 (6): 438-445, 2022. Coenzyme Q10 and vitamin E ameliorate mercury toxicity. Groups of 6 healthy weaning male Wistar rats each were given 30ppm methyl mercury (30Me-HG) in drinking water, 30MeHg with 5mg/kg CoQ10 by gavage, 30MeHg with 10mg CoQ 10 and 30MeHg with 350ppm Vitamin E in ration. Compared with results in normal control untreated rats, lesions attributed to mercury were in order of severity as follows: deep cerebellar nuclei, cerebral cortex, hippocampus, cerebellum, caudate putamen and corpus collosum. At necropsy, rats given 30MeHg had increased cerebrospinal fluid, meningeal opacity, edema, slight congestion and brain swelling. Histology revealed edema in perivascular spaces, neuronal swelling and necrosis, hyperemia, central chromatolysis, neuronophagia, glial nodule formation, satellitosis, perivascular cuffing with lymphocytosis and scattered macrophages. Rats treated with coenzyme 10mg/kg Q10 showed a reduction in neuron necrosis and gliosis in deep cerebellar nuclei and caudate putamen. In Rats given Vitamin E, severity of the lesions was reduced but again type of lesions did not change.
KEYWORDS: Coenzyme Q10, Vitamin E, Methyl mercury, Rat brain.