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OJVRTM

 

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 28 (9): 514-521, 2024.

Effect of meloxicam on disposition of ceftriaxone in febrile goats.

 

Rohit R, Singh V, Ram M, Kumar V, Singh KK, Roy BK.

 

College of Veterinary Science, Ranchi-Jharkhand, India.

ABSTRACT

 

Rohit R, Singh V, Ram M, Kumar V, Singh KK, Roy BK, Effect of meloxicam on disposition of ceftriaxone in febrile goats., Onl J Vet Res., 28 (9): 514-521, 2024. Groups of 6 normal and febrile female goats were injected 50mg/kg intramuscular ceftriaxone with or without 0.5mg/kg meloxicam. Fever was induced by 0.2 µg/kg intravenous lipopolysaccharide of Escherichia coli serotype 0126:B8. Plasma ceftriaxone was determined by high performance liquid chromatography at 0.08 to 24h with 15 intervals. Compared with controls, in febrile goats, peak plasma ceftriaxone was 34%, clearance 42, absorption 67 and elimination 58% higher (P < 0.01) but AUC 41 and residence time 57% lower (P < 0.001). In goats given meloxicam, plasma  peak levels were 23, aborption 35 an elimination 33 higher but meloxicam had no effect on clearance. Results suggest 7.44 mg/kg ceftriaxone may be injected intramuscularly in goats with 0.5mg/kg meloxicam every 10.36h to maintain therapeutic levels.

 

Keywords:    Pharmacokinetics; Ceftriaxone; Meloxicam; Intramuscular; Febrile; Goats.

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