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OJVRTM

 

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 28 (8): 481-489, 2024.

Chromatography and disposition of meloxicam in volunteer plasma.

 

Selvadurai Muralidharan, Janaki Sankarachari Krishnan Nagarajan, Chandran Sathish Vimal, Anil Dubala and Renjith George

 

Center for Advanced Drug Research and Testing, College of Pharmacy, Rocklands, Ooty, Tamilnadu, India.

 

ABSTRACT

 

Muralidharan S, Nagarajan JSK , Vimal CS, Dubala A, George R., Chromatography and disposition of meloxicam in volunteer plasma, Onl J Vet Res., 28 (8): 481-489, 2024. A liquid chromatographic method for meloxicam tablets in healthy human plasma and its bioequivalence is described. Twelve healthy volunteers were given 15mg meloxicam or reference formulation. Plasma meloxicam was determined by protein precipitation separated by reversed-phase 150 × 4.6mm, 5µ SPHER C18 column with mobile phase of acetonitrile:Tetrahydrofuran: 0.5% Triethylamine pH 3.5 flow rate of 1 ml/min detected at 363nm. The method was linear over 75.00-2000.00 ng/ml with r = > 0.99, limit of detection was 1.0ng/ml and quantification 3.0ng/ml. Peak plasma meloxicam was 646 ± 145 ng/ml, AUC0–72 27700 ± 6340 ng/h/ml and clearance 0.0305±0.0046 ng/ml/h

 

Keywords: Meloxicam, chromatography, bio-equivalence, disposition, plasma, volunteers.

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