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Online Journal of Veterinary Research©
Volume 22 (10):901-904, 2018.
Effect of dietary melatonin on peroxidation markers and testes weights in Albino male rats
given 1% hydrogen peroxide in drinking water over 30 days.
Khalid Ahmed Hadi1, Wasan Sarhan oubied2, Raouf Mikdam Fadhil3, Ahmed Abdulaali Azeez4
1,2,3 Department(s) of Physiology, Biochemistry and Pharmacology , Faculty(s) of Veterinary Medicine, Tikrit university, 4Kirkuk University, Tikrit, Iraq.
Hadi KA, Oubied WS, Fadhil RM, Azeez AA., Effect of dietary melatonin on peroxidation markers and testes weights in Albino male rats given 1% hydrogen peroxide in drinking water over 30 days, Onl J Vet Res., 22 (10):901-904, 2018. Four groups of 15 male albino rats each were given daily 40mg/kg dietary melatonin and 1% hydrogen peroxide (HP) in drinking water daily for 30 days (group 1), HP (2) or melatonin (3) only. Controls were fed normally and given only drinking water (4). Blood was taken at 30 days for serum testosterone, glutathione, luteonizing hormone, Malondialdehyde (MDA) and peroxynitrite. Rats were sacrificed for testes weight. Compared with water controls, in rats given only HP, testosterone and glutathione declined 44 and 57% but peroxynitrites and MDA increased ~146 and 37% (P < 0.05). In those given HP with melatonin there was also a decline (P <0.05) in glutathione of 35%. Melatonin alone reduced (P < 0.05) MDA 36% compared with control and 54% compared with those given HP. We found no difference in testes weights between any group. Results suggest no effect of melatonin of peroxidation markers given to rats ingesting HP, but it did reduce serum MDA compared with controls.
Key words: Melatonin, testosterone, glutathione, malondialdehyde, raw data provided upon request.