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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X


Volume 27 (7): 420-427, 2023.

Serum leptin, adiponectin, insulin, C-reactive protein, long-chain linolenic acid omega 3 and obesity in Mastiff dogs.


Amir Hossein Asgari Safdar


Young Researchers Elite Club, Baft Branch, Islamic Azad University, Baft, Iran.




Asgari Safdar AH., Serum leptin, adiponectin, insulin, C-reactive protein and serum long-chain linolenic acid omega 3 and obesity in Mastiff dogs, Onl J Vet Res., 27 (7): 420-427, 2023. Author describes relationship between leptin, Canine C-reactive protein (CRP), adiponectin, and insulin to body condition score (BCS) and long-chain omega-3 fatty acids alpha-linolenic acid, eicosapentaenoic acid (EPA), docosapentanenoic acid (DPA), and docosahexaenoic acid (DHA) in 77 Persian Mastiff dogs. Multivariate regression was applied to determine correlations between these variables. Results showed that linoleic and arachidonic acids were most abundant ~14 % whereas α-linoleic, docopentanoic and eicopentanoic acids ranged 0.18-1.53%. Enhanced adiponectin correlated (P < 0.001) with age, EPA and DHA acids but not with obesity. Enhanced serum leptin was associated (P < 0.05) with increased serum BCS, DPA and DHA. Highly significant (P < 0.0001) correlations existed between BCS and leptin between lean and obese dogs but not between overweight and obese ones. DPA was negatively associated with enhanced leptin but we found no link between DHA, DPA and BCS and age (P > 0.36). Higher serum insulin was associated (P < 0.001) with BCS in lean, overweight, and obese dogs. Results suggest long-chain linolenic acid omega 3 supplements may manage obesity in Mastiff dogs.


Keywords: obesity, dog, adiponectin, omega-3 fatty acid, insulin, leptin