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OJVRTM

Online Journal of Veterinary Research©

 Volume 22 (2): 160-164, 2018.

Infectivity of a human Salmonella mdandaka isolate in organs of BALB/C mice.

 

Zinah Shakir Shallal1 and Afaf Abdulrahman Yousif2.

 

1Deptarment of Biology, College of Science, University of Wasit, 2Dept. of Internal and Preventive Veterinary Medicine, College of Veterinary Medicine, University of Baghdad, Iraq. Corresponding author :-E mail:- Afaf_a.rahman@yahoo.com.

 

ABSTRACT

 

Shallal ZS, Yousif AA, Infectivity of a human Salmonella mdandaka isolate in organs of BALB/C mice, Onl J Vet Res., 22 (2): 160-164, 2018. Infectivity and distribution of a human Salmonella mbandaka isolate in tissues of balb/cmice are described. Twenty two BALB/C mice were drenched with an infective dose of 1.3×107 cells/ml Salmonella mbandaka isolated from a hospitalized dehydrated child suffering fever and severe diarrhea. Another 22 mice were used as 0.5ml PBS controls. Mice were sacrificed 24, 48, 72, 96, 120, 144 and 168 hours and 2, 4, 6 and 8 weeks after treatment. Salmonella mbandaka was isolated from ileum, liver, spleen, gallbladder, kidney, lung and brain, and cultured on brilliant green, Salmonella-Shigella and Xylose-Lysine Deoxycholate agars. Salmonella mbandaka was found in higher numbers in the small intestine especially the ileum more than internal organs. During the first stage of infection, Salmonella mbandaka spread to Ileum, liver, gallbladder, spleen, heart, kidney, and lung but with varying infectivity over time. We also found the bacteria in the brain of a mouse 168 hours post-infection. These differences may be due to the route of inoculation, infectivity of S. mbandaka or host.

 

Keywords: Salmonellosis, Salmonella mdandaka, infective dose and bacterial isolates.

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