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OJVRTM
Online Journal of
Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 27 (4): 217-223, 2023.
Genomic
prediction for T lymphocyte epitopes on Plasmodium
falciparum.
Singh SP, Khan F, Mishra BN.
Institute of
Engineering & Technology, U. P. Technical University,
Sitapur Road, Lucknow, India.
Singh SP, Khan F, Mishra BN., Genomic prediction for T lymphocyte epitopes on Plasmodium falciparum
(Malaria). Onl J Vet Res., 27 (4): 217-223, 2023. A
barrier to vaccination against malaria is life cycle of Plasmodium falciparum which expresses different antigens during each
stage. The P. falciparum genome (23
Mb) encodes more than 5300 proteins, each a potential target of protective
immune responses. Because immune responses to Plasmodium are dispersed over a large number of antigens an
effective vaccine should include immunogenic epitopes of its genome highly
conserved across different strains and stages.
ProPred and ProPred1 were used to predict
genome/proteome promiscuous helper T lymphocytes (HTL) and cytotoxic T
Lymphocytes (CTL) epitopes in P.
falciparum. We identified epitopes from a large number of antigens for
reverse vaccinology not limited by growth or gene expression.
KEY-WORDS: Malaria, Plasmodium falciparum, genomics,
proteomics, subunit vaccine, T-cell, epitope.