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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 27 (4): 217-223, 2023.
Genomic prediction for T lymphocyte epitopes on Plasmodium falciparum.
Singh SP, Khan F, Mishra BN.
Singh SP, Khan F, Mishra BN., Genomic prediction for T lymphocyte epitopes on Plasmodium falciparum (Malaria). Onl J Vet Res., 27 (4): 217-223, 2023. A barrier to vaccination against malaria is life cycle of Plasmodium falciparum which expresses different antigens during each stage. The P. falciparum genome (23 Mb) encodes more than 5300 proteins, each a potential target of protective immune responses. Because immune responses to Plasmodium are dispersed over a large number of antigens an effective vaccine should include immunogenic epitopes of its genome highly conserved across different strains and stages. ProPred and ProPred1 were used to predict genome/proteome promiscuous helper T lymphocytes (HTL) and cytotoxic T Lymphocytes (CTL) epitopes in P. falciparum. We identified epitopes from a large number of antigens for reverse vaccinology not limited by growth or gene expression.
KEY-WORDS: Malaria, Plasmodium falciparum, genomics, proteomics, subunit vaccine, T-cell, epitope.