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OJVRTM
Online Journal of Veterinary Research
Established 1994

ISSN 1328-925X

Volume
25(4):291-300, 2021.


Genome-wide prediction for malaria vaccine epitopes in P. falciparum

 

Satarudra Prakash Singh (PhD), Feroz Khan (PhD) and BN Mishra (PhD)

 

1,2,3 Department of Biotechnology, Institute of Engineering & Technology, U. P. Technical University, Sitapur Road, Lucknow-226021 (U.P.) INDIA.

 

ABSTRACT

 

Singh SP, Khan F, Mishra BN., Genome-wide prediction for malaria vaccine epitopes in P. falciparum, Onl J Vet Res., 25(4):291-300, 2021. Effective malarial vaccine is hampered by life cycle of Plasmodium falciparum, which expresses complex antigens during development. Plasmodium does not grow well in cell culture so that computation could be used to develop an In silico vaccine. P. falciparum genome (23 Mb) encodes >5300 proteins, potential targets for immune response. Current subunit vaccines target a single or few antigens and thus cannot elicit wide response. Immune responses to Plasmodium are dispersed on a relatively large number of parasite antigens and an effective vaccine should target immunogenic regions or epitopes of the Plasmodium genome/proteome that are highly conserved. We report PROPED prediction of genome/proteome promiscuous helper T and cytotoxic T lymphocyte epitopes in P. falciparum for malaria vaccine.

 

Key-words: Malaria, Plasmodium falciparum, genomics, proteomics, subunit vaccine, T-cell, epitope, bioinformatics.