Volume 23 (6):585-593, 2019.
Effect of Origanum majorana on augmentin induced effects on liver cell DNA and oxidation
markers in albino mice.
Thannon Burhan Salih and Ali H Saliem.
College of Veterinary Medicine,
University of Baghdad, Iraq
Salih TB, Saliem
AH., Effect of Origanum majorana
on augmentin induced effects on liver cell DNA and
oxidation markers in albino mice, Onl J Vet Res., 23 (6):585-593,
2019. We report effect of Origanum majorana on liver cell DNA fragmentation
and serum catalase, gluthathione (GSH) and maldonehyde (MDA) in albino male mice given large doses of augmentin for 21 days. Four groups of 10 mice each were gavaged 81mg/kg augmentin twice
daily with (1) or without 300mg/kg Origanum majorana extract (2) or 100mg/kg silymarin
(3) for 21 days. Controls were given water (4). Cardiac blood was taken at 21
days for serum MDA, GSH and Catalase and mice sacrificed for liver tissue and DNA
fragmentation tests by gel electrophoresis. Compared with controls, serum MDA
increased (P < 0.05) ~33 to 55% in mice given augmentin
or silimarin but not in those given O majorana. Serum
catalase declined (P < 0.05) ~62 to 74% but not in mice given extract. However
gluthathione declined (~31-48%) in all mice (P < 0.05).
We found only some samples of all mice except controls to show DNA
Fragmentation. The findings suggest that O
majorana may exert antioxidant properties in
presence of augmentin.
Key-Words: Augmentin, Origanum, liver
cell, oxidation, DNA fragmentation, mice. Raw data provided.
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