Volume 23 (6):585-593, 2019.
Effect of Origanum majorana on augmentin induced effects on liver cell DNA and oxidation markers in albino mice.
Thannon Burhan Salih and Ali H Saliem.
College of Veterinary Medicine, University of Baghdad, Iraq
Salih TB, Saliem AH., Effect of Origanum majorana on augmentin induced effects on liver cell DNA and oxidation markers in albino mice, Onl J Vet Res., 23 (6):585-593, 2019. We report effect of Origanum majorana on liver cell DNA fragmentation and serum catalase, gluthathione (GSH) and maldonehyde (MDA) in albino male mice given large doses of augmentin for 21 days. Four groups of 10 mice each were gavaged 81mg/kg augmentin twice daily with (1) or without 300mg/kg Origanum majorana extract (2) or 100mg/kg silymarin (3) for 21 days. Controls were given water (4). Cardiac blood was taken at 21 days for serum MDA, GSH and Catalase and mice sacrificed for liver tissue and DNA fragmentation tests by gel electrophoresis. Compared with controls, serum MDA increased (P < 0.05) ~33 to 55% in mice given augmentin or silimarin but not in those given O majorana. Serum catalase declined (P < 0.05) ~62 to 74% but not in mice given extract. However gluthathione declined (~31-48%) in all mice (P < 0.05). We found only some samples of all mice except controls to show DNA Fragmentation. The findings suggest that O majorana may exert antioxidant properties in presence of augmentin.
Key-Words: Augmentin, Origanum, liver cell, oxidation, DNA fragmentation, mice. Raw data provided.