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OJBTM
Online
Journal of Bioinformatics ©
Volume 15
(1): 54-86, 2014.
Functional diversity of melanoma
antigen proteins implicated in tumor/cancer related pathways.
Daniel
A Achinko PhD1,3. Awino Maureiq Edith Ojwank2,
Anton Dormer MD3.
1International
Center of Insect Physiology and Ecology (ICIPE), Nairobi, Kenya, 2University of Nairobi, Kenya, P.O
Box 30197, G.P.O, Nairobi, Kenya, 3PepVax, Inc.10411 Motor City Drive
Bethesda, MD 20817, USA.
ABSTRACT
Achinko DA, Ojwank AME, Dormer A., Functional
diversity of melanoma antigen proteins implicated in tumor/cancer related
pathways. Onl J Bioinform., 15 (1): 54-86, 2014. Evidence
showing that the functional diversity of melanoma antigen proteins (MAGE) variants
and their putative interactions could favor malignancy of tumors is described.
Through protein-protein interaction networks, four core proteins (HDAC1, RARA,
P53 and SNW1) were identified as the foundation of all the processes governing
the MAGE protein network. The involvement of these proteins in various cancer
pathways implicated one of the complexes predicted within the MAGE protein
network and this complex was dominantly MAGE subclass A proteins. MAGE B2 was
identified among the hubbal nodes making it the most
essential and lethal protein for the MAGE protein network. Involvement of MAGE proteins
variants in different tumors makes them potential molecules for a common
vaccine target and marker for early molecular diagnosis. Driver mutations
associated with the four core proteins favoring tumor progression of MAGE proteins
could be exploited through genome wide association studies (GWAS) for the
development of early molecular detection kits.
Key Words-Melanoma antigen proteins, cancer pathways,
vaccine.