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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 26 (12): 920-948, 2022.
Functional diversity of melanoma antigen proteins.
Daniel A Achinko PhD1,3. Awino Maureiq Edith Ojwank2, Anton Dormer MD3.
1International Center of Insect Physiology and Ecology (ICIPE), Nairobi, Kenya, 2University of Nairobi, Kenya, P.O Box 30197, G.P.O, Nairobi, Kenya , 3PepVax, Inc.10411 Motor City Drive Bethesda, MD 20817, USA.
Achinko DA, Ojwank AME, Dormer A., Functional diversity of melanoma antigen proteins, Onl J Vet Res., 26 (12): 920-948, 2022. Evidence showing functional diversity of melanoma antigen proteins (MAGE) variants and interactions that could favor malignancy of tumors is described. Through protein-protein interaction networks, HDAC1, RARA, P53 and SNW1 proteins were identified as foundation for processes governing MAGE protein network. Involvement of these proteins in various cancer pathways implicated subclass A protein MAGE B2 as an essential lethal protein and potential molecule vaccine target and marker for diagnosis.
Key-Words: Melanoma, antigen, functional, diversity