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OJVRTM

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X

 

Volume 26 (12): 920-948, 2022.


Functional diversity of melanoma antigen proteins.

 

Daniel A Achinko PhD1,3. Awino Maureiq Edith Ojwank2, Anton Dormer MD3.

1International Center of Insect Physiology and Ecology (ICIPE), Nairobi, Kenya, 2University of Nairobi, Kenya, P.O Box 30197, G.P.O, Nairobi, Kenya , 3PepVax, Inc.10411 Motor City Drive Bethesda, MD 20817, USA.

 

ABSTRACT

 

Achinko DA, Ojwank AME, Dormer A., Functional diversity of melanoma antigen proteins, Onl J Vet Res., 26 (12): 920-948, 2022. Evidence showing functional diversity of melanoma antigen proteins (MAGE) variants and interactions that could favor malignancy of tumors is described. Through protein-protein interaction networks, HDAC1, RARA, P53 and SNW1 proteins were identified as foundation for processes governing MAGE protein network. Involvement of these proteins in various cancer pathways implicated subclass A protein MAGE B2 as an essential lethal protein and potential molecule vaccine target and marker for diagnosis.

 

Key-Words: Melanoma, antigen, functional, diversity


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