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OJVRTM
Online Journal of
Veterinary Research©
(Including Medical
and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume
26 (12): 920-948, 2022.
Functional diversity of melanoma
antigen proteins.
Daniel
A Achinko PhD1,3. Awino Maureiq Edith Ojwank2,
Anton Dormer MD3.
1International
Center of Insect Physiology and Ecology (ICIPE), Nairobi, Kenya, 2University of Nairobi, Kenya, P.O
Box 30197, G.P.O, Nairobi, Kenya , 3PepVax, Inc.10411 Motor City
Drive Bethesda, MD 20817, USA.
ABSTRACT
Achinko DA, Ojwank AME, Dormer A.,
Functional diversity of melanoma antigen proteins, Onl
J Vet Res., 26 (12): 920-948, 2022. Evidence showing functional diversity
of melanoma antigen proteins (MAGE) variants and interactions that could favor
malignancy of tumors is described. Through protein-protein interaction
networks, HDAC1, RARA, P53 and SNW1 proteins were identified as foundation for
processes governing MAGE protein network. Involvement of these proteins in
various cancer pathways implicated subclass A protein
MAGE B2 as an essential lethal protein and potential molecule vaccine target
and marker for diagnosis.
Key-Words:
Melanoma, antigen, functional, diversity
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