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OJVR
Online Journal of Veterinary Research©
Volume 13 (2):128-135, 2009. Extensively
redacted 2017.
Respiratory macrophage activity and
pulmonary morphology following exposure to benzo(a)pyrene
in broilers.
Latif IK1
(DVM, MS), Karim AJ1 (DVM, MS), Zuki ABZ1
(DVM, PhD), Zamri-Saad
M1 (DVM, PhD, Niu
JP2 (MD, MS), Noordin MM1 (DVM,
MS, PhD).
1Faculty
of Veterinary Medicine, Universiti Putra Malaysia,
43400 Serdang, Selangor, Malaysia,2School
of Public Health, Lanzhou University, 73000 Lanzhou, China.
ABSTRACT
Latif
IK, Karim AJ, Zuki
ABZ, Zamri-Saad M, Niu JP, Noordin MM, Respiratory
macrophage activity and pulmonary morphology following exposure to
benzo(a)pyrene in broilers, Onl J Vet Res, 12
(2):128-135, 2009. We describe effect of benzo(a)pyrene (BaP) on macrophage
defense system and lung morphology in broilers.
Groups of 40 chicks each were given 1.5 or 150
μg or 15mg/kg BaP
intra- tracheal (IT), for 5 consecutive days. Controls chicks were given tricaprylin IT. Ten birds from each group were then
sacrificed at days 7, 14, 21 and 35. Respiratory lavage was performed
immediately to procure avian respiratory macrophages (ARM). A significant
decrease in mean lavage volume, phagocytosis and intracellular killing
activities along with an increase in ARM counts was observed especially in the
group receiving 15mg
BaP indicating a
possible immune-pulmonary toxic effect of inhaled BaP.
Keywords: benzo(a)pyrene, intra-tracheal, macrophage, toxicity,
broiler