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Online Journal of Veterinary Research©
Volume 13 (2):128-135, 2009. Extensively redacted 2017.
Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers.
Latif IK1 (DVM, MS), Karim AJ1 (DVM, MS), Zuki ABZ1 (DVM, PhD), Zamri-Saad M1 (DVM, PhD, Niu JP2 (MD, MS), Noordin MM1 (DVM, MS, PhD).
1Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia,2School of Public Health, Lanzhou University, 73000 Lanzhou, China.
Latif IK, Karim AJ, Zuki ABZ, Zamri-Saad M, Niu JP, Noordin MM, Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers, Onl J Vet Res, 12 (2):128-135, 2009. We describe effect of benzo(a)pyrene (BaP) on macrophage defense system and lung morphology in broilers. Groups of 40 chicks each were given 1.5 or 150 μg or 15mg/kg BaP intra- tracheal (IT), for 5 consecutive days. Controls chicks were given tricaprylin IT. Ten birds from each group were then sacrificed at days 7, 14, 21 and 35. Respiratory lavage was performed immediately to procure avian respiratory macrophages (ARM). A significant decrease in mean lavage volume, phagocytosis and intracellular killing activities along with an increase in ARM counts was observed especially in the group receiving 15mg BaP indicating a possible immune-pulmonary toxic effect of inhaled BaP.
Keywords: benzo(a)pyrene, intra-tracheal, macrophage, toxicity, broiler