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OJVRTM
Online
Journal of Veterinary Research©
Volume
20(12):755-760, 2016.
Connective tissue and lymphocyte density in mesenteric
lymph node of cats infected
naturally with feline
leukemia virus (FeLV) and FeLV
negative controls.
Flávia Azevedo Cavalcanti de Melo1, André Rodrigues da
Cunha Barreto Vianna1, Anna Clara dos Santos1,
Danila Barreiro Campos2, Kaique Nogueira1,
Eduardo Maurício Mendes de Lima1
1University of Brasilia, Faculty of Agronomy
and Veterinary Medicine, Laboratory of Anatomy of Domestic Animals, 70910-970,
Brasília, Distrito Federal, Brazil. 2Federal University of Paraíba Corresponding author: limaemm@unb.br
ABSTRACT
Melo FAC, Barreto Vianna ARC, Santos AC, Campos DB, Nogueira
K, Lima EMM., Density of connective tissue and lymphocytes in mesenteric lymph
node of cats infected naturally with feline leukemia virus (FeLV)
and FeLV negative controls, Onl
J Vet Res., 20(12):755-760, 2016. Feline Leukaemia Virus (FeLV) is a gama-retrovirus which infects domestic cats and wild
felines inducing immunosuppression, anemia and lymphoma. Density of connective
tissue and lymphocytes in mesenteric lymph node in cats infected naturally by FeLV and negative controls is described. Lymph nodes were
excised after euthanasia, cut, fixed and stained to calculate area occupied by
lymphocytes and density of connective tissue with image Pro-Plus 6.0®. Mean
density of lymphocytes in cats (n=4) with FeLV was
20.45% ± 0.97 and connective tissue density 4.7% ± 0.28. The same values in
negative FeLV controls (n=5) were 14.75% ± 0.43 (P
< 0.0001) and 3.98% ± 0.18 (P < 0.0383), respectively. An increase in
density of lymphocytes in FeLV-infected
animals was an unexpected result since
the literature describes immunosuppression. The increase suggested immune reactivity with
hyperplasia.
Key-words: FeLV,
immunosuppression, morphometry, lymphocytes, connective tissue, lymphoid
tissue, feline.