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Online Journal of Veterinary Research©
(including medical and laboratory research)
Volume 22 (10):941-951, 2018.
Effect of Ganoderma lucidum supplement on kidney function markers and histology
in Albino rats given hydrogen peroxide in drinking water for 30 days.
Abdullah BA 1, Sarhat ER 2, Owain MS3.
Department(s) of Pharmacology1, Basic Sciences2, College of Veterinary Medicine, Dentistry College3, University of Tikrit1,2
Abdullah BA , Sarhat ER, Owain MS., Effect of Ganoderma lucidum supplement on kidney function markers and histology in Albino rats given hydrogen peroxide in drinking water 30 days, Onl J Vet Res., 22 (10):941-951, 2018. We describe effect of dietary Ganoderma lucidum (GL) Reichi mushroom on kidney function markers in four groups of 5 rats each given 0.5% hydrogen peroxide in drinking water (HPD) (Group 1) with Vitamin C (2) or 0.03gm GL in feed daily for 30 days (3). Controls were fed basal diet with water only (4). At Day 30, blood samples were taken for serum serum urea, creatinine, cystatin C and lipocalin-2 and rodents were sacrificed for microscopy of kidney tissue. Compared with controls, by day 30, in those given peroxide serum urea was 40% higher and with Vitamin C 27% higher, creatinine 39%, cystatin 70-141% and lipocalin 29% higher (P < 0.05). However, we found no significant difference in any value between controls and rats fed Ganoderma lucidum in feed. Compared with normal kidneys, microscopy of kidney sections in rats given HPD revealed degeneration of glomeruli in cortex, clots in interstitial veins, and desquamated tubular epithelial cells. With exception of a few atrophic glomeruli and degenerated epithelial lumen cells, most structures appeared normal in rats given ganoderma supplement.
Key Words: Ganoderma lucidum, peroxide toxicity, kidney, rats. Raw data provided upon request.