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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 25 (8):508-514, 2021.
Effect of mastitis on disposition kinetics of levofloxacin following single dose oral administration in goats.
Mahendra Ram, Vishakha Singh, Birendra Kumar Roy* and Kaushal Kumar Singh
Dept. of Pharmacology & Toxicology, College of Veterinary Science & A. H., Ranchi -834006, Jharkhand, India.
Ram M, Singh V, Kumar Roy B, Kumar Singh K., Effect of mastitis on disposition kinetics of levofloxacin following single dose oral administration in goats, Onl J Vet Res., 25 (8):508-514, 2021. We report pharmacokinetics of single oral dose of 25 mg/kg levofloxacin (LVX) in 6 mastitis and 6 healthy control Bengal goats. Mastitis was induced by coagulase positive Staphylococcus aureus. Blood and milk LVX were determined by HPLC for pharmacokinetic parameters. Therapeutic plasma LVX sustained 36h in controls and 48h in goats with mastitis peaking at 11.18 ± 0.41 at 2h and 13.29 ± 1.12μg/ml at 1h, respectively. In milk, we found similar values but reached only 7.57 ± 0.67 in controls and 8.42 ± 0.85 µg/ml (P > 0.05) in those with mastitis. Compared with controls, half-life’s were ~32% longer (p < 0.01) in plasma of mastitic goats with corresponding ~31% slower (P < 0.05) clearance. There were no differences in apparent volumes of distribution and protein binding was 27.46 ± 4.48%. We find that levofloxacin persists longer in milk and plasma of goats with mastitis caused by Staphylococcus aureus. We find that 8 mg/kg LVX every 40h will inhibit S aureus mastitis in goats.
Key words: Pharmacokinetics, levofloxacin, goats, mastitis, oral.