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OJBTM
Online Journal
of
Bioinformatics
©
Volume
14 (2): 138-145,
2013
Subtractive genomic
identification of drug
targets in Leishmania Donovani
and L. Infantum.
Tanima
Shree (MSc)1, Suhail
Ahmad Khan (B.Tech)2, Shivanjali
Saxena (B.Tech)3.
1Institute
of
Computational Biology, Domlur
Layout, Bangalore,
Karnataka, 2,3Amity University Campus, Malhaur,
Gomti Nagar Extension, Lucknow,
Uttar Pradesh, India.
ABSTRACT
Shree
T,
Khan SA, Saxena S., Subtractive
Genomic
identification of drug targets in Leishmania
Donovani and Infantum, Onl
J Bioinform., 14(2):138-145,
2013. Subtractive genomics can
identify genes
essential to a human parasite not present in a host to
identify drug targets
against Leishmania spp. Three potential
proteins in Leishmania Donovani
and Infantum are described which
did
not share sequence homology to human proteins when
compared against
genes present in the Database of Essential Genes. Glyoxylase
II and 2-Hydroxymethyl-5-(7-methylamino-imidazol[4,5-b]pyridin-3-yl)-tetrahydro-furan-3-ol(HEMBL405920)
were
identified as targets in Leishmania infantum
which bind to non-conserved residues in the
human enzyme.
Keywords:
Subtractive genomics, Leishmaniasis,
Virtual
screening, Kala-azar, Therapeutic
targets,
Sub-cellular location.