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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 26 (12): 866-879, 2022.
Drug targets for Chlamydophila pneumoniae
Reddy EH, Satpathy GR
1Department of Biotechnology and Medical Engineering, National Insitute of Technology, Rourkela, India.
Reddy EH, Satpathy GR., Drug targets for Chlamydophila pneumoniae, Onl J Vet Res., 26 (12): 866-879, 2022. Whole genome sequences of Chlamydophila pneumoniae and four strains were analyzed to identify common drug targets. A substractive genomic approach was done to identify Holliday junction DNA helicase RuvB as common non-human homologous gene amongst the four strains. A 3D model of Holliday junction DNA helicase RuvB protein was generated by homology modelling with most likely ligands selected by biological and chemical properties interaction with target proteins. Docking was done with the different conformations of each ligand. Two lead molecules for designing drugs against the pathogen were identified by considering the physical and chemical aspects of their binding to the protein. In this paper, we predicted Holliday junction DNA helicase RuvB protein as novel drug target and by inhibiting its activity we can control the pneumonia. This in silico analysis provides a rapid and potential approach for the identification of drug targets and design of drug lead molecules.
Keywords: Chlamydophila pneumoniae, homology modeling, drug targets, docking, drug design.