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Online Journal of Veterinary Research©
Volume 24 (1):28-37, 2020.
Effect of ..Lavandula angustifolia on cisplatin cytotoxicity in MCF-7 breast cancer cell line.
Sedigh-Ardekani Mozhgan1, Fazeli Mehdi2*, Masoudian Maliheh3, Ghahramani Seno Mohammad Mahdi4*
1Department(s) of Biotechnology, 2Basic Sciences, 3Central Lab. School of Veterinary Medicine, Shiraz University, Shiraz, 4Division of Biotechnology, Department of Pathobiology and Department of Basic Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Mozhgan SA, Mehdi F, Maliheh M, Mohammad Mahdi GS., Effect of Lavandula angustifolia on cisplatin cytotoxicity in MCF-7 breast cancer cell line, Onl J Vet Res., 24 (1):28-37, 2020. Chemotherapy to manage breast cancer may affect normal and cancer cells as well as inducing resistance requiring lower initial dosages. Herbal extracts per se are not used to treat cancer but as supplements may reduce adverse effects and drug resistance associated with chemotherapy. We report effect of lavender flowers Lavandula angustifolia on cytotoxicity of cisplatin on MCF-7 breast cancer cell line. Extracts characterized by gas chromatography-mass spectrometry (GC/MS) identified linalool, Camphor, 1,8-cineole, lavandulyl acetate, borneol, linalyl acetate and β-bisabolene. MTT assay was used to determine the cytotoxicity index (IC50) of the lavenderís hydro methanolic extract on MCF-7 and MCF10A normal breast cell line for 24 or 48 hrs. The cells were then co-treated with the extract and cisplatin at various concentrations for 24 or 48 hrs. Results suggested that the extract per se was slightly toxic to normal breast cells (MCF-10A) but given with cisplatin inhibited MCF-7 cancer cells ~60% at 24h or 48h (P < 0.05).
Keywords: Lavandula angustifolia, breast cancer, MCF-7, MCF-10A, cisplatin, herbal medicine. Raw data provided.