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OJVRTM
Online Journal of
Veterinary Research©
Volume 19(2): 130-136, 2015.
Effects of Ketotifen on
fertility in sub-fertile (Achillea millefolium L.) male
mice
Sabooreh
Farazi1, Mohammad Chamani1*.
1Department of Animal Science, Faculty of
Agriculture and Natural Resources, Tehran Science and Research Branch, Islamic
Azad University, Tehran, Iran.
ABSTRACT
Farazi
S, Chamani M., Effects of Ketotifen
on fertility in sub-fertile (Achillea millefolium L.) male mice, Onl J Vet Res., 19(2): 130-136, 2015. Three groups of 6 adult male NMRI mice each
weighing 28±1 g were injected IP 200 mg/kg BW Achillea millefolium L.
for 20 days to induce a sub-fertile status. The extract was not given to a
group of solvent controls. Mice were then gavaged 30
or 50 μg/g Ketotifen
daily for 30 days and fertility parameters were compared with solvent and Achillea millefolium L
controls. Differences in body weight before and after administration,
testicular weight index, epididymal mass index, sperm
count and motility, fertilization rate and plasma concentrations of
testosterone were measured. Compared with Achillea
millefolium L controls body weight was lower in
mice gavaged 30 or 50 ug/g Ketotifen, but epididymal weight
index was higher in those given 30 μg/g and
sperm count higher in those given 50 μg/g ketotifen. Testicular weight index, sperm motility, plasma
concentration levels of testosterone and the number of newborns in both groups
receiving Ketotifen were also higher compared to Achillea millefolium L
controls.
Keywords: Mast cell, Ketotifen,
parameters of fertility, sub-fertile male mouse
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