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OJVRTM

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 29 (4): 178-181, 2025.

Effects of vitamin C on ketamine-diazepam anesthesia in dogs.

Marjani M, Selk Ghaffari M¹, Bahonar AR, Yazdanpanah Abdolmaleki A¹.

Faculty of Veterinary Medicine, Islamic Azad University-Karaj Branch. University of Tehran, Iran.

ABSTRACT

Marjani M, Selk Ghaffari M, Bahonar AR, Yazdanpanah Abdolmaleki A Effects of vitamin C on ketamine-diazepam anesthesia in dogs, Onl J Vet Res, 29 (4): 178-181, 2025. Effect of intravenous 100 and 500mg/kg vitamin C on ketamine-diazepam (K+D) anesthesia was evaluated in 4 groups of five 20-27kg mixed ~1 year old breed dogs of both sexes. Baseline heart, respiratory rates, temperature, glucose and calcium were determined. Groups were anaesthetized by 10mg/kg intravenous (IV) K and 0.5mg/kg D (1), pre-medicated IV by 100 (2) or 500mg/kg (3) vitamin C [EPS1] 30 minutes before K+D. Controls (4) were given saline. [EPS2] Compared with controls by 30 minutes, heart rates increased (P < 0.04) 37-48% in dogs injected K+D with or without Vitamin C. Compared with dogs injected K+D we observed increases of ~1C in those given vitamin C. Blood glucose declined 23-34% (P < 0.04) in animals given K + D with or without Vitamin C. Compared with dogs given only K+D and duration of anesthesia was shortened ~46% in those given Vitamin C.

Key words: vitamin C, ketamine, diazepam, anesthesia, dog.

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