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OJBTM
Online Journal of Bioinformatics©
Volume 8 (2) : 154-164,
2007
The 3D structure of the Japanese Encephalitis helicase, using homology
based molecular modelling techniques
Vlachakis D, Brancale A
ABSTRACT
Vlachakis D, Brancale A., The 3D structure of the Japanese Encephalitis helicase, using homology based molecular modelling
technique, Online J Bioinformatics 8 (2) 154-164, 2007. The helicase plays a key
role in the life cycle of viruses of the Flaviviridae family.
Japanese encephalitis virus is a member of this family and constitutes an
important human pathogen (1). In this
work, towards a structure-based design of novel anti-japanese
encephalitis agents, a 3D-model of the japanese
encephalitis helicase virus was produced using
homology modelling techniques and the known 3D-structure of the yellow fever helicase of the Flaviviridae family as template.
Keywords: Homology modelling; Molecular Dynamics; Helicase; Japanese Encephalitis Virus; Flaviviridae.