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OJVRTM
Online Journal of
Veterinary Research©
Volume 18(7): 612-622, 2014.
Effect of Ivermectin on
blood and immunological markers in rainbow trout (Oncorhynchus mykiss).
Siavash Soltaniana1 (DVM, phD), Mohammad
Nabi Adloob (MSc)
& Nastaran Ghadimib(MSc)
aAquatic Animal Health &
Diseases Department, School of Veterinary Medicine, Shiraz University bDepartment of fisheries, Science and Research
Branch, Islamic Azad University, Tehran, Iran.
ABSTRACT
Soltanian
S, Nabi AdloobM, Ghadimib N., Effect of Ivermectin
on blood and immunological markers in rainbow trout (Oncorhynchus
mykiss), Onl J Vet Res., 18(7): 612-622,
2014.
Effects of single doses of 25, 50 and 100 µg/kg-1
intraperitoneal (IP)
injections of Ivermectin on hematological and
immunological markers in juvenile rainbow trout Oncorhynchus
mykiss are reported. Controls
were injected sterile saline IP or not injected. Blood was
collected 3, 7, 10 and 14 days after injection for immunological and
biochemical analyses. Phagocytic index (Pi) and activity,
lysozyme, nitroblue tetrazolium activity (NBT),
leucocytes (WBC), erythrocytes (RBC), total plasma protein (TPP),
immunoglobulin (Ig), hematocrit
(HT) and hemoglobin (Hb) were measured. Compared with
controls, Hb, HT and RBC were not affected by any
dose of Ivermectin. Results suggest that 50ug/ kg-1 Ivermectin may induced elevations in Pi, NBT, Ig,
TPP and WBC peaking 14 days after injection. There was no mortality, or any
difference in body weight and length between controls and treated fish.
Keywords:
Rainbow trout, ivermectin, hematological and
immunological parameters, pesticide, antiparasitic
drug.
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