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OJVRTM
Online Journal of Veterinary Research©
Volume 20(6):389-395,
2016.
Electrocardiographic changes in Holstein calves
after dexamethasone and isoflupredone administration.
Aliasghar Chalmeh*, Seyyed Mohammad Mehdi Heidari, Mohammad Reza Zarei, Mehrdad Pourjafar, Saeed Nazifi
School of
Veterinary Medicine, Shiraz University, Shiraz, Iran
ABSTRACT
Chalmeh A, Mehdi Heidari
SM, Zarei MR, Pourjafar M, Nazifi S., Electrocardiographic changes in Holstein calves
after dexamethasone and isoflupredone administration,
Onl J Vet Res.,
20(6):389-395,
2016. Glucocorticoids can
cause serum electrolyte imbalance affecting membrane action potentials. Two groups of 5 Holstein 6-10 month old calves were given 1mg/kg
intramuscular dexamethasone sodium phosphate or 1mg/kg isoflupredone
acetate on 2 consecutive days. Blood samples were taken at day 0 (1st administration),
1 (2nd administration), 2, 3,
5 and 7 for determination of serum Na+, K+, Cl-,
Ca+, Mg+ and P+. Electrocardiograms were
recorded from calves on same day of blood samplings. Duration of S and T waves, amplitude of S and R waves and P-R, R-R,
S-T and Q-T intervals increased (P<0.05) after dexamethasone and isoflupredone administration. R-amplitude decreased to base line at 5th
and 7th days in both groups. Serum K+, Cl-,
Ca+ and P+ concentrations declined (P<0.05) after
isoflupredone administration and were lower than in
cows given dexamethasone. Findings suggest that changes in serum electrolytes
may have been due to isoflupredone and dexamethasone
affecting ECG. The result must be interpreted with caution as they were not
compared with saline controls.
Keywords: Glucocorticoids, Electrolyte imbalances,
Cardiac action potential, Electrocardiography, Holstein calves.
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