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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X


Volume 26 (11): 788-794, 2022.

Tetracycline resistance genes in Escherichia coli isolated from dogs exposed to salinomycin.


Sohrabi Z1, Hosseinzadeh S1, Rajaian H2, Derakhshandeh A4, Mazaheri Nezhad Fard R4.


1School(s) of Veterinary Medicine, Shiraz University and 2University of Tehran, Iran




Sohrabi Z, Hosseinzadeh S, Rajaian H, Derakhshandeh A, Nezhad Fard, R., Tetracycline resistance genes in Escherichia coli isolated from dogs exposed to salinomycin., Onl J Vet Res., 26 (11): 788-794, 2022. Epidemic antimicrobial resistance in various bacteria has been considered as a major threat to human health. Resistance to tetracycline has increased in Escherichia coli, mostly encoded by tetA gene due to extensive use and transfer of gene to bacteria. We developed an in vivo dog model to assess tetA encoded tetracycline resistance in E. coli in presence of salinomycin. Results showed similar resistance in dogs treated with salinomycin and tetracycline or receiving tetracycline alone confirmed by PCR. In summary, no effect of salinomycin was observed on tetracycline resistance of commensal E. coli isolated from dogs.


Keywords: Antimicrobial resistance, Tetracycline, Ionophore, salinomycin.