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OJVRTM
Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 27 (5): 267-272, 2023.
Bovine tuberculosis g-interferon and
interleukin-2 receptor tests in cattle.
Ritelli M, Amadori M, Dondo A, Begni B, Zoppi S, Archetti
IL.
ABSTRACT
Ritelli
M, Amadori M, Dondo A, Begni B, Zoppi S, Archetti IL. Bovine
tuberculosis g-interferon and
interleukin-2 receptor tests in cattle. Onl J Vet Res., 27 (5): 267-272, 2023. Inconclusive
g-interferon receptor tuberculosis tests can be resolved by inducing expression
of interleukin-2 receptor as immune marker for M. bovis
on same blood sample. Seventy-five of 765 samples were g-interferon positive
(9.8%), 9 dubious (1.18%) and 14 negative. Sixty four cattle had same result by
both tests (67.4%). Of 95 cattle slaughtered, 38 were TB lesion-positive with
36 g-interferon positive and 2 dubious. By IL-2 R assay, 33 scored positive, 1
negative and 4 dubious. No g-interferon negatives scored positive by IL-2R assay
but 10 g-interferon positive and dubious samples scored negative. Forty-two
g-interferon positive and 34 dubious M. bovis-positive
or suspect farms tested by IL-2R assay yielded 16 SICT-positive. Thirty-five of
42 g-interferon positive were positive by IL-2R assay, 5 negative and 2
dubious. Twenty g-interferon dubious animals were scored positive but 10
negative by IL-2R assay and 4 dubious. By SICT 13 of 16 were positive in IL-2R
assay (81%). We found no discrepancy with IL-2R assay for g-interferon negative
cattle. Blood from M. bovis-positives
appeared negative by g-interferon or IL-2R assays. We find both tests to have
low specificity but high agreement.
KEYWORDS:
Cattle, tuberculosis, tests, g-interferon,
interleukin-2,
receptors.
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