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OJVRTM®
Online Journal of Veterinary Research©
Volume 3:41-49, 1999. Redacted 2018.
Immunogenicity of influenza glycoproteins with
different forms of supramolecular organization in hens
A P Bogoyavlenskiy, V E Berezin, V P Tolmacheva, S S Khudyakova, A V Ogneva..
Laboratory of Antivirus Protection, Institute of Microbiology &
Virology, Almaty, Kazakhstan, Address for correspondence A.P. Bogoyavlenskiy: Laboratory of Antivirus Protection,
Institute of Microbiology & Virology, Almaty, Kazakhstan.
ABSTRACT
Bogoyavlenskiy AP, Berezin VE, Tolmacheva VP, Khudyakova SS, Ogneva AV., Immunogenicity of influenza glycoproteins with
different forms of supramolecular organization in hens, Onl
J Vet Res, 3:41-49, 1999. The
immunogenicity of an influenza A subunit vaccine
preparation administered to hens in glycoprotein micelles, complex of
glycoproteins with glycoside Quil A, and
glycoproteins mixed with complete Freund's adjuvant were assessed in
comparative studies with formalinized whole virus. The results showed that
immunization of the influenza antigen preparations induced variable levels of
antibodies at 14, 21, 35, 77, 98 and 300 days post-immunization. Immune
Stimulating complexes (ISCOMs) were the most efficient antigen formulation of
purified FPV glycoproteins stimulating a higher level of humoral immunity than
whole virus or glycoprotein micelles. ISCOMs also stimulated a high level of antibodies
in egg-yolk. Egg-yolk antibody titers were correlated with the level of serum
antibodies.
KEYWORDS:
humoral immunity, influenza vaccines, ISCOMs
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