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Online
Journal of Bioinformatics ©
In Silico drug targets for infectious
endocarditis
Priyadarshini V, Pradhan D,
Munikumar M, Swargam
S, Umamaheswari A,
Rajasekhar D., In Silico
drug targets for infectious endocarditis, Online J Bioinform 14 (1): 32-50, 2013. Availability
of
pathogens and the human genome sequence have facilitated
identification of
common drug targets against infective endocarditis (IE). By
implementing
comparative and subtractive genomics with metabolic pathway
analysis, 18 common
putative drug targets were identified for 8 major pathogens of
IE. MurB was the only target
found to use the peptidoglycan
biosynthesis pathway unique to bacteria. MurB
target
was therefore chosen to be modeled (Modeller9v8). From the
predicted model,
allosteric site residues
were located and validated through CASTp
analysis. The
In Silico
drug targets reported here could be used to design drug
molecules against
infective endocarditis.
Keywords: Infective
endocarditis, MurB, Peptidoglycan
biosynthesis, Molecular modeling, Modeller.