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Online Journal of Veterinary Research©
Volume 24(7): 401-406, 2020.
Effect of alhagi camelorum, ziziphus spina christi and levisticum officinale extracts
on blood glucose in normal and diabetic rats.
Mohammadi Abbass1, Emadi Ladan2, Barghi Maryam3.
1Physiology Research Center, Kerman University of Medical Sciences, Kerman and Department of biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman,2Department of Basic Sciences, 3School of Veterinary Medicine, Shahid Baahonar University of Kerman, Iran.
Abbass M, Ladan E, Maryam B., Effect of alhagi camelorum, ziziphus spina christi and levisticum officinale on blood glucose in normal and diabetic rats, Onl J Vet Res., 24(7): 401-406, 2020. Glucosidase inhibitors are currently used to manage metabolic disorders such as diabetes. We report effect of methanolic extracts of Alhagi camelorum, Ziziphus spinachristi and Levisticum officinal on blood glucose in normal and diabetic male Wistar rats. Diabetes was induced with streptozotocin. Groups of 6 diabetic and non-diabetic rats each were gavaged 2g/kg maltose with 1000mg/kg of each plant extract after 15h food deprivation. Controls were given 2gr/kg maltose with or without 50 mg/kg acarbose. Blood glucose was determined by glucometer 0, 30, 60 and 120 min after treatments. In non-diabetic rats, 2gr/kg maltose increased (P < 0.05) blood glucose ~23-38% (from ~100 to 160mg/dl) by 30-60 minutes, but gavaged with 50mg/kg acarbose did not affect sugar blood. L. officinal extract increased glucose ~33%, A. Camelorum ~16-33% to 120 minutes and Z. spinachristi ~18-20% to 60min with no diffrenecs with control values. In diabetic rats given maltose, glucose reached 586.1± 21.2mg/dl by 60min and with acarbose or L. officionalis and blood glucose rose ~20%. However, in rats given A camelorum or Z. spina Christi blood glucose did not increase significantly suggesting these extracts may induce anti-diabetic effects in rats.
Keywords: Diabetes mellitus, Alpha glucosidase, Alhagiacamelorum and Ziziphusspina and levisticum officinal.