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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 26 (4): 269-279, 2022.

Effect of salinomycin on thyroid hormones, homocysteine and antioxidant trace elements in sheep.


H Rajaian, S Nazifi, S Sedaghat, A Hajimohammadi, E Mohsenifard, A Mirzaei


Departments of Basic Sciences and Clinical Studies, School of Veterinary Medicine, Shiraz University, Iran





Rajaian H, Nazifi S, Sedaghat S, Hajimohammadi A, Mohsenifard E, Mirzaei A., Effect of salinomycin on thyroid hormones, homocysteine and antioxidant trace elements in sheep, Onl J Vet Res., 26 (4): 269-279, 2022. Salinomycin is fed to ruminants for growth and poultry to treat coccidiosis but high doses can induce toxicity. We report effects of single injection of 0.75, 1.5 and 3mg/kg intravenous salinomycin on serum homocysteine (Hcy), triiodothyronine (T3), thyroxine (T4), selenium (Se), copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) over 17 days in sheep. Control were injected IV 20 ml distilled water. Compared with controls, serum homocysteine increased 22-39% but iron declined 13-43% and selenium 15-39% (P < 0.001-0.05). These changes were dose dependent. We found no effect on thyroid hormones or other trace metals. Results suggest salinomycin IV may induce dose dependent myocardial and muscular tissue damage.

Key words: Salinomycin toxicosis, Sheep, Thyroid hormones, Homocycteine, Antioxidant trace elements.