2021-2032 All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under International copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editor.


OJVRTM

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 26 (4): 269-279, 2022.


Effect of salinomycin on thyroid hormones, homocysteine and antioxidant trace elements in sheep.

 

H Rajaian, S Nazifi, S Sedaghat, A Hajimohammadi, E Mohsenifard, A Mirzaei

 

Departments of Basic Sciences and Clinical Studies, School of Veterinary Medicine, Shiraz University, Iran

 

 

ABSTRACT

 

Rajaian H, Nazifi S, Sedaghat S, Hajimohammadi A, Mohsenifard E, Mirzaei A., Effect of salinomycin on thyroid hormones, homocysteine and antioxidant trace elements in sheep, Onl J Vet Res., 26 (4): 269-279, 2022. Salinomycin is fed to ruminants for growth and poultry to treat coccidiosis but high doses can induce toxicity. We report effects of single injection of 0.75, 1.5 and 3mg/kg intravenous salinomycin on serum homocysteine (Hcy), triiodothyronine (T3), thyroxine (T4), selenium (Se), copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) over 17 days in sheep. Control were injected IV 20 ml distilled water. Compared with controls, serum homocysteine increased 22-39% but iron declined 13-43% and selenium 15-39% (P < 0.001-0.05). These changes were dose dependent. We found no effect on thyroid hormones or other trace metals. Results suggest salinomycin IV may induce dose dependent myocardial and muscular tissue damage.

Key words: Salinomycin toxicosis, Sheep, Thyroid hormones, Homocycteine, Antioxidant trace elements.


MAIN

 

 

FULL-TEXT (SUBSCRIBE OR PURCHASE ARTICLE)