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OJVRTM
Online
Journal of Veterinary Research©
Volume 20(6):396-402, 2016.
Immuno-expression of HER-3, HER-4 and REα in canine mammary
carcinomas.
Luisa Martelli1, Anderson do Prado Duzanski1,2,
Haline Fêo Ballestero Msc1,
Luis Gabriel Rivera-Calderón LG Msc1,
Luis Mauricio Montoya-Flórez PhD 1,3, Noeme
Sousa Rocha PhD1.
1Department(s) of Clinical Veterinary
Medicine, Faculty of Veterinary Medicine, São Paulo State University-UNESP, Botucatu, SP, Brazil, 2Department of Pathology,
Faculty of Medicine, São Paulo State University, UNESP, SP, Brazil, 3Veterinary
Pathology Research Group, Faculty of Agricultural Sciences, Universidad de
Caldas, Manizales, Colombia
ABSTRACT
Martelli L, Duzanski AP, Ballestero HF,
Rivera-Calderón LG, Montoya-Flórez
LM, Rocha NS., Immuno-expression of HER-3, HER-4 and REα in canine mammary
carcinomas, Onl J Vet Res., 20(6):396-402, 2016. Mammary neoplasms are the most
common tumors in bitches that when malignant, produce high mortality due to
recurrence or metastases. About 50 to 70% of mammary carcinomas positive for
estrogen receptors (ER) have better prognoses than ER negative tumors. Aside
from ER there are other biomarkers of prognostic value in mammary carcinomas
such as epidermal growth factors (HER). However, these receptors are still
seldom explored in veterinary oncology. We describe expression of receptors
HER-3, HER-4 and REα in 112 canine mammary neoplasm samples from The
Laboratory of Investigative and Compared Pathology (UNESP, Botucatu
Campus, State of São Paulo, Brazil). Samples underwent immune-histochemical assay (IHC) for
HER-3 and HER-4 antibodies employing crescent intensity and distribution scores
0, 1+, 2+ and 3+. For Reα antibody, cases with
over 10% of the neoplastic cells with positive nuclear marking were considered
positive. One hundred ten (98.21%) samples were positive for HER-3 and 107
(95.53%) positive for HER-4. Sixty samples (53.57%) were positive for REα.
Findings suggest HER-3, HER-4 and Reα were expressed differently in canine
mammary neoplasms. Clinical studies are needed to establish how expression of
these receptors affects incidence, recurrence and aggressiveness of tumors.
KEY WORDS: neoplasm, mammary gland, bitches, estrogen receptors, epidermal growth
factor receptor.
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