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Online Journal of Veterinary Research©
Volume 21 (12):784-793, 2017.
Effect of Anethum graveolens aqueous extract on blood fasting glucose and hematological parameters in diabetic male BALB/c mice
Erfan Bahrami1, Mohammad Reza Khedri1, Mohammad Mahdi Zangeneh1*, Mohammad Abiari1, Akram Zangeneh2, Amir Amiri-Paryan2, Reza Tahvilian3, Rohallah Moradi3
Department (s) of 1Clinical, 2Microbiology Section, Pathobiology & Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah. 3Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. *Corresponding Author: Mohammad Mahdi Zangeneh *Email: firstname.lastname@example.org
Bahram E, Khedri MR, Zangeneh MM, Abiari M, Zangeneh A, Amiri-Paryan A, Tahvilian R, Moradi R., Effect of Anethum graveolens aqueous extract on blood fasting glucose and hematological parameters in diabetic male BALB/c mic, Onl J Vet Res., 21 (12):784-793, 2017 Anethum graveolens (AG) or Dill has been used in ayurvedic medicine since ancient times. We describe effect of AG on blood glucose and hematological parameters in diabetic mice. Diabetes was induced in 60 BALB/c mice by intraperitoneal injection of 60 mg/kg streptozotocin (STZ). Fasting blood glucose (FBG) was determined daily and mice with > 250mg/kg were used for further study. After 3 days, groups of 10 diabetic mice each, were gavaged 20 mg/kg glibenclamide orally or 10, 20, 40 and 80 mg/kg AG aqueous extract (AGAE) daily for 20 days. Two groups served as non-diabetic and untreated diabetic controls. Blood for fasting glucose and hematological parameters were taken at 1, 4, 7, 10, 13, 16 and 20 days. Results suggested that treatment with 40 and 80 mg/kg AGAE reduced FBG and affected blood cell and platelet counts.
Keywords: Anethum graveolens, aqueous extract, diabetic, mice.