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Online Journal of Veterinary Research©
Volume 24(7): 420-427, 2020.
Effect of gold chloride trihydrate on serum liver enzymes and liver histology in male versus female rabbits.
Mustafa Fadhil1, Bahaa Fakhri Hussein1, Muhammed Mizher Radhi2
1College of Veterinary Medicine, University of Baghdad, 2Radiology Dept., Health and Medical Technology College-Baghdad, Middle Technology University (UTM), Iraq.
Fadhil M, Hussein BF, Radhi MM., Effect of gold chloride trihydrate on serum liver enzymes and liver histology in male versus female rabbits, Onl J Vet Res., 24(7): 420-427, 2020. Gold derivatives are used to treat rheumatoid arthritis and cancer. Authors describe changes in serum liver enzymes and histopathology in male and female rabbits injected 2, 3 and 4mg/kg gold chloride subcutaneously daily for 45 or 90 days. Blood was taken and rabbits sacrificed at 45 and 90 days. Compared with controls we found large increases (~57%) in mean serum alkaline phosphatase by 90 days in both sexes. Gold chloride at any dose induced severe anemia in female rabbits with red cells declining ~59-96% (P < 0.001). Platelets increased in both and hemoglobin remained within normal limits. By 45 days treatment, we found large increases in white blood cells (~45-71%) and lymphocytes (~71%) in female rabbits but not in males. In males these values only increased by 90 days and with higher doses. Compared with untreated controls we observed pathological changes in hepatocytes, portal triads and sinusoids including anisokaryosis, nuclear vesiculation, binucleation, cytoplasmic inclusions, cytoplasmic swelling, hydropic degeneration and necrosis. Our hematology/sera results suggest that gold chloride may be more toxic in female rabbits.
KEY WORDS: Gold chloride, rabbits, serum liver, enzymes, hepatotoxicity, histology.