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Online Journal of Veterinary Research
Volume 17 (2): 73-81, 2013. Redacted 2017.

Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes


Adza Rina M.N.1, Zamri-Saad M.1*, Jesse F.F.A.2, Saharee A.A.2, Haron A.W.2, Shahirudin S.3


1Research Centre for Ruminant Diseases, 2Department of Veterinary Clinical Studies, 3Department of Veterinary Pathology & Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia




Adza Rina MN, Zamri-Saad M, Jesse FFA, Saharee AA, Haron AW, Shahirudin S., Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes, Online J Vet Res., 17 (2): 73-81, 2013. This study describes lesions and clinical responses that develop in goats following experimental infection with Corynebacterium pseudotuberculosis by intradermal, intranasal and oral administration. Three groups of 5 goats each were given 1 ml inoculum containing 107 cfu/ml live Corynebacterium pseudotuberculosis by intradermal, intranasal, and oral routes, respectively. Controls were not inoculated. Goats were assessed for clinical signs, body temperature, blood cell count and serum biochemistry. The animals were euthanized 30 days after exposure and pre-scapular, submandibular, supra-mammary, inguinal and mesenteric lymph nodes, lung, liver and kidneys were excised for bacterial isolation and histopathology examinations. Compared with controls, goats inoculated with Corynebacterium pseudotuberculosis showed higher body temperatures at week 1 which returned to normal by week 2. Intradermal infection increased leukocytes and ALT levels and induced severe abscesses in lymph nodes. Pulmonary congestion, liver abcesses, splegnomegalia and renal congestion were found. Intradermal infection was related with abscesses in pre-scapular and submandibular lymph nodes whereas intranasal and oral exposure with mesenteric lymph nodes. Results suggest that intradermal C pseudotuberculosis infection in goats may induce more severe widespread lesions compared with other routes of administration.


Key words: Pathology, Corynebacterium pseudotuberculosis, goats