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OJVRTM
Online Journal of Veterinary Research©
Volume 1: 29-34, 2002.
Redacted 2018.
Oral acute toxicity of glyphosate in Wistar rats
Dallegrave Ea, DiGiorgio MFa, Dalsenter PR,b Langeloh Aa
aDepartment of Pharmacology, Instituto de Ciências Básicas da Sáude, Universidade Federal do
Rio Grande do Sul, Porto Alegre/RS, Brazil. bDepartment of
Pharmacology, Instituto de Ciências
Biológicas, Centro Politécnico,
Universidade Federal do Paraná, Curitiba/PR, Brazil.
Address for correspondence:Eliane Dallegrave,
Mestre em Ciências Veterinárias, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul
Rua Sarmento Leite / 500, sala 202, 90046-900
- Porto Alegre/RS. Brasil. Email: elianed@vortex.ufrgs.br
ABSTRACT
Dallegrave E, Mantese FD, Dalsenter PR, Langeloh A., Oral acute toxicity of glyphosate in Wistar rats, Onl J Vet Res.,
1:29-34, 2002. The acute toxicity of glyphosate (N-phosphonomethylglycine with the surfactant polyoxyethyleneamine:Roundup®) was determined 2, 4, 6, 8,
10, 12 and 24 hours after oral administration of 1, 2, 3 or 4g/kg to Wistar rats. Each animal was observed for immediate
toxicity up to 12h and for death up to 24h. Signs of toxicity included
salivation, diarrhea, gasping, blood-stained nose discharges and seizures. Post
mortem examination showed lung hyperemia and liver congestion. The oral acute
LD50 was found to be 31g/kg (95%confidence limits = 1.81 – 2.95) in Wistar rats, a value 54% lower than that reported in the
literature (> 5g/kg).
KEYWORDS: Glyphosate; N-phosphonomethylglycine;
polyoxyethyleneamine; DL50; rats; Acute toxicity; Roundup®.
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