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OJVRTM

Online Journal of Veterinary Research

Volume 23 (5):414-424, 2019


Effects of chronic oral monosodium glutamate on body weight and liver histology in Wistar rats.

 

Ali A Tala'a2 and Amer M Hussin1

 

1Belad Al-Rafidain University College, Diyala, 2College of Veterinary Medicine, University of Fallujah, Iraq.

 

ABSTRACT

 

Tala'a AA, Hussin AM., Effects of chronic oral monosodium glutamate on body weight and liver histology in Wistar rats, Onl J Vet Res., 23 (5):414-424, 2019. Groups of 8 mature Wistar male rats were given daily 15mg oral monosodium glutamate (MSG) 30 or 75 days. Eight controls were given water. Rats were sacrificed at days 30 and 75 for liver tissue, microscopy, cytology and mitotic index, and blood for serum AST and ALT. Compared with controls, body weights increased ~28-37% and liver weights ~8-14% (p < 0.05). Hepatocytes were 24-26% more numerous and hyperplastic (11-19%), nuclei 41-44%, and binucleated cells 55-62% more frequent in rats given GMS. Apoptotic and Kupffer cells increased 37-57% and serum AST 47% and ALT 60% Our findings suggest that chronic intake of high doses of GMS may affect rat livers.

 

Keywords: Chronic MSG, liver, rat, weight. Raw data provided after Reference list.


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