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OJVRTM
Online
Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
26 (10): 739-745, 2022.
Amino acid sequences
of glutamate dehydrogenase in fungi,
plants and mammals.
Vivek Dhar Dwivedi MSc, Sarad Kumar Mishra PhD.
Department of Bioinformatics,
Uttaranchal College of Science & Technology, DDU, Gorakhpur - University, Department
of Biotechnology, Dehradun, India.
Abstract
Dwivedi VD, Mishra SK., Amino acid sequences of glutamate
dehydrogenase in fungi, plants and mammals, Onl J Vet
Res., 26 (10): 739-745, 2022. Glutamate
dehydrogenase
in microbes and mitochondria of eukaryotes
converts glutamate
to α-ketoglutarate and vice versa. We
report full-length amino acid sequences from fungi, plants and animals for
multiple sequence alignment, pattern and domain identification, composition and
phylogenetic tree. We found 6 glycine, 2 glutamic acid and asparagine, and one
aspartic acid, tyrosine, alanine, valine, serine and leucine each in all
species, in fungi and mammals, 5 glycine, 2 glutamic acid and proline and 1
arginine and alanine and in plants and fungi, 5 glycine, 3 glutamic acid, 2
praline and 1 threonine, arginine, alanine, asparagine, tryptophan, and leucine
residues. However in all plant and animals we found 5 amino acid residues
pattern of different lengths. By phylogenetic analysis we constructed one cluster of plant and animal origin and another for fungi.
We found ~10% glycine a very high frequency compared with other amino acids and
10 unique motifs. These findings suggest conserved
amino acid residues were essential for evolution of glutamate dehydrogenase
evolution from lower fungi to higher mammals.
Keywords: Glutamate dehydrogenase, amino
acids, sequences, fungi, plants, mammals.