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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
26 (10): 739-745, 2022.
Amino acid sequences of glutamate dehydrogenase in fungi, plants and mammals.
Vivek Dhar Dwivedi MSc, Sarad Kumar Mishra PhD.
Department of Bioinformatics, Uttaranchal College of Science & Technology, DDU, Gorakhpur - University, Department of Biotechnology, Dehradun, India.
Dwivedi VD, Mishra SK., Amino acid sequences of glutamate dehydrogenase in fungi, plants and mammals, Onl J Vet Res., 26 (10): 739-745, 2022. Glutamate dehydrogenase in microbes and mitochondria of eukaryotes converts glutamate to α-ketoglutarate and vice versa. We report full-length amino acid sequences from fungi, plants and animals for multiple sequence alignment, pattern and domain identification, composition and phylogenetic tree. We found 6 glycine, 2 glutamic acid and asparagine, and one aspartic acid, tyrosine, alanine, valine, serine and leucine each in all species, in fungi and mammals, 5 glycine, 2 glutamic acid and proline and 1 arginine and alanine and in plants and fungi, 5 glycine, 3 glutamic acid, 2 praline and 1 threonine, arginine, alanine, asparagine, tryptophan, and leucine residues. However in all plant and animals we found 5 amino acid residues pattern of different lengths. By phylogenetic analysis we constructed one cluster of plant and animal origin and another for fungi. We found ~10% glycine a very high frequency compared with other amino acids and 10 unique motifs. These findings suggest conserved amino acid residues were essential for evolution of glutamate dehydrogenase evolution from lower fungi to higher mammals.
Keywords: Glutamate dehydrogenase, amino acids, sequences, fungi, plants, mammals.