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Online Journal of Veterinary Research

Volume 23 (3):220-225, 2019.

Effect of 30 and 75 day gavage of monosodium glutamate on

renal structure and creatinine in adult male Wistar rats.


Amer M Hussin* and Ali A. Tala'a** Belad Al-Rafidain.


**University College, Diyala,*College of Veterinary Medicine, University of Fallujah, Iraq.




Hussin AM, Tala'a AA, Al-Rafidain B., Effect of 30 and 75 day oral monosodium glutamate on renal histomorphology in adult male Wistar rats, Onl J Vet Res., 23 (3):220-225, 2019. Authors describe effects of oral monosodium glutamate (MSG) on renal histomorphology in Wistar rats. Groups of 8 mature male rats each were gavaged a daily dose of 15mg/kg MSG for 30 or 75 days. Controls (n=8) were given water. Compared with controls, in rats given MSG for 75 days, we measured increased (P < 0.05) basement membrane diameters () of ~8%, Bowmans capsule ~12%, Bowmans space ~18%, diameter of proximal convoluted tubule ~13%, lumen ~26% and cell height ~10%, diameter of the distal tubule increased 15% but there was no effect on lumen diameter, cell number or height. There were large increases (38%) in number of mesangial cells in glomeruli. We found no significant changes in renal structures in rats given MSG for only 30 days. However, serum creatinine increased (P < 0.05) 43% in rats given MSG 30 days and 68% in those gavaged 75 days. Possibly, monosodium salt of glutamic acid may accumulate in kidney and chronic ingestion of MSG at 15mg/kg daily for 75 days may induce changes in renal structures.


Keywords: MSG, Rat, kidney, creatinine. Raw data provided.