Volume 23 (3):220-225, 2019.
Effect of 30 and 75 day gavage of monosodium
glutamate on
renal structure and creatinine in
adult male Wistar rats.
Amer M Hussin*
and Ali A. Tala'a** Belad
Al-Rafidain.
**University College, Diyala,*College of Veterinary Medicine, University of
Fallujah, Iraq.
ABSTRACT
Hussin AM, Tala'a AA, Al-Rafidain B., Effect of 30 and 75 day oral monosodium
glutamate on renal histomorphology in adult male Wistar rats, Onl J Vet Res., 23 (3):220-225, 2019. Authors
describe effects of oral monosodium glutamate (MSG) on renal histomorphology in Wistar rats. Groups
of 8 mature male rats each were gavaged a daily dose of 15mg/kg MSG for 30 or
75 days. Controls (n=8) were given water. Compared with controls, in rats given
MSG for 75 days, we measured increased (P < 0.05) basement membrane
diameters (µ) of ~8%, Bowmans capsule ~12%, Bowmans space
~18%, diameter of proximal convoluted tubule ~13%, lumen ~26% and cell height ~10%,
diameter of the distal tubule increased
15% but there was no effect on lumen diameter, cell number or height. There
were large increases (38%) in number of mesangial cells in glomeruli. We found no significant changes in renal structures
in rats given MSG for only 30 days. However, serum creatinine increased (P <
0.05) 43% in rats given MSG 30 days and 68% in those gavaged
75 days. Possibly, monosodium salt of glutamic acid may accumulate in kidney
and chronic ingestion of MSG at 15mg/kg daily for 75 days may induce changes in
renal structures.
Keywords: MSG, Rat, kidney, creatinine. Raw
data provided.
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