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OJVRTM
Online
Journal of Veterinary Research©
Volume 18(8): 680-687, 2014.
Expression
of glucagon-like peptide-2 receptor in bovine rumen epithelial and
gastrointestinal tissues.
Amir Hossein Asgari
Safdar1*, Saeed Pour Mahdi Ghaem Maghami2
Young Researchers and Elite Club, 1Baft
2Karaj Branch, Islamic Azad University, Baft,
Karaj, Iran
ABSTRACT
Asgari Safdar AH, Ghaem
Maghami SPM., Expression of glucagon-like peptide-2 receptor
in bovine rumen epithelial and gastrointestinal tissues, Onl
J Vet Res., 18(8): 680-687, 2014. The
presence of glucagon9like peptide92 receptor (GLP92R) in bovine rumen
epithelium and gastrointestinal tract tissue from 4 steers is reported. Results from quantitative RT9PCR indicated
GLP92R mRNA in the rumen epithelium, omasum, abomasum, duodenum, jejunum,
ileum, large intestine and pancreas.
Expression of mRNA for GLP92R in pre-gastric bovine tissues was numerically
less than in lower gastrointestinal tract tissue. The greatest expression of mRNA for GLP92R
was in the small and large intestine.
The jejunum and ileum had numerically greater concentrations of GLP92R
mRNA than the duodenum whereas rumen epithelium and abomasum had the lowest
levels. Western blot analysis revealed
the greatest density of GLP92R protein in rumen epithelium obtained from the
ventral sac. Results of this
investigation demonstrate the presence of the glucagon9like peptide92 receptor
in bovine tissue responsible for mediating the actions of hormone GLP92. Further investigations are warranted to
determine the actions and potential implications of GLP92 in the bovine.
Key
Words: Glucagon-like peptide-2,
Bovine, Rumen epithelial, Expression.
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