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OJBTM
Online Journal of Bioinformatics©
Volume 11
(1):98-102, 2009
Prediction of
3-Dimensional Structure of GLI2 of Homo
sapiens.
Sreekanth P, Narayan J.
Bioinformatics Centre, Amity
Institute of Biotechnology,
ABSTRACT
Sreekanth P, Narayan J.,
Prediction of 3-Dimensional Structure of GLI2 of Homo sapiens, Online J
Bioinformatics, 11 (1):98-102, 2009. Gli2
is a transcriptional activator, even though it is also suggested to have a weak
repressing activity. Gli2 is expressed in the interfollicular
epidermis and the outer root sheath of hair follicles in normal human skin and
it is able to induce G1–S phase progression in contact-inhibited keratinocytes which may drive tumour
development. Studies have also shown that GLI2 plays a dual role as activator
of keratinocyte proliferation and repressor of
epidermal differentiation. For the structure prediction with homology modeling,
a template protein was obtained by BLASTp and the
predicted 3-D model may be used to characterize the protein in a wet
laboratory.
Keywords: Transcriptional activator, homology
modeling, Homo sapiens, 3-D model, PDB, Swiss model, predictive model,
Swiss-PdbViewer, PROCHECK, Ramachandran
plot.