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Online Journal of Veterinary Research©
Volume 22 (4):304-314, 2018.
Effect of vitamin C on gentamicin-induced nephrotoxicity in albino rats.
Amin Derakhshanfar*1, Arash Bidadkosh2, Ali Roshanzamir3.
Department of Pathology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Derakhshanfar A, Bidadkosh A, Roshanzamir A., Effect of vitamin C on gentamicin-induced nephrotoxicity in albino rats, Onl J Vet Res., 22 (4):304-314, 2018. We report dose-related effect of vitamin C on gentamicin-induced nephrotoxicity in rats. Groups of 10 Albino rats each were injected IM daily for 10 days with 80mg/kg gentamicin, 200mg/kg vitamin C and 80mg/kg gentamicin with 100 or 200mg/kg Vitamin C. Five controls were given saline. Compared with controls, in rats given only gentamicin, plasma malondialdehyde (MDA) increased and creatinine clearance, serum sodium, potassium and cytoplasmic superoxide dismutase decreased (P < 0.05). In those given gentamycin with 200mg/kg vitamin C, we found declines in creatinine clearance, increased plasma MDA and reduced serum sodium (P < 0.05). We found minimal changes in renal tissue in rats given higher doses of vitamin C with gentamycin.
Keywords: Gentamicin, Vitamin C, Nephrotoxicity, Rat, Superoxide dismutase, Lipid peroxidation.