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OJVRTM

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 28(1): 1-5, 2024.


Pharmacokinetics of Gentamicin in buffalo calves after IV administration.

 

Sushma Lalita Baxla1, C. Jayachandran2, Birendra Kumar Roy3, Ravuri Halley Gora3

 

Sushma Lalita Baxla1, C.Jayachandran2, Birendra Kumar Roy3, Ravuri Halley Gora 3Dept. of Veterinary Pharmacology & Toxicology, College of Veterinary Science & A. H., 2Bihar Veterinary College Patna, 3Birsa Agricultural University, Ranchi, India.

 

ABSTRACT

 

Baxla SL, Jayachandran C, Roy BK, Gora RH., Pharmacokinetics of Gentamicin in buffalo calves after IV administration, Onl J Vet Res., 28 (1): 1-5, 2024.  We report disposition kinetics of gentamicin after single intravenous dose of 5mg/kg in 5 buffalo calves. Mean peak plasma 19.80 1.36g/ml occurred at 0.042h still detected by 24h with a mean levels of 0.023 0.03g/ml. Mean therapeutic gentamicin (≥ 2 g/ml) was maintained 6h in plasma whereas in urine 48h with a mean peak of 83.42 3.17 g/ml at 1.5h and a mean therapeutic concentration ≥ 2 g/ml for 24h. Distribution rate constant was 1.058 0.100 h-1 and distribution half life 0.69 0.08h suggesting rapid distribution. The elimination rate constant of 0.139 0.008h-1 and elimination half-life of 5.05 0.30h suggested slow elimination at 0.351 0.023h-1 with a total body clearance of 1.86 0.16ml/kg/min from the central compartment. High mean residential time of 5.79 0.34h suggested that gentamycin levels remained for a longer period in buffalo calves compared with other animals. The high Vdarea of 0.80 0.04L/kg was supported by a tissue to plasma concentration of 1.54 0.16.

 

Key words: Pharmacokinetics, gentamicin, buffalo calves, intravenous.


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