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OJBTM
Online Journal of
Bioinformatics©
Volume 1
(19):14–19, 2018.
GC dispersion in
non-coding RNAs from E.coli K12 genome.
Sridhar J,
Rafi ZA
Centre of Excellence in Bioinformatics,
School of Biotechnology, Madurai Kamaraj University,
Madurai 625021, India.
ABSTRACT
Sridhar J, Rafi ZA GC dispersion in non-coding RNAs from E. coli K12 genome. Onl J Bioinform 1 (19):14–19, 2018. Non-coding RNAs (ncRNAs) are
primary transcripts which exert their function directly in the cell instead of
coding for amino acids. The GC distribution of ncRNAs
in the entire E.coli K12 genome
(RNome) was analyzed. GC distribution in coding genes
was illustrated with tRNA, rRNA,
sRNA and intergenic regions. Results showed that 83% of sRNAs
GC distribution ranged from 45% to 52%. A shift in GC content of tRNA genes decoding polar-charged (non-hydrophobic) and
hydrophobic amino acids and a correlation between the GC distribution and tRNA iso-types was found. This
study suggests that tRNA iso-types
having low GC% may decode non-hydrophobic amino acids and high GC%, hydrophobic
ones.
Key words: %GC, ncRNA, GC bias, hash value, sRNA.
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