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OJVRTM
Online Journal of Veterinary Research©
(Including Medical and Laboratory
Research)
Established 1994
ISSN 1328-925X
Volume 28 (9): 530-536, 2024.
Effect
of paracetamol induced liver pathology on disposition of gatifloxacin
in turkeys.
Kaushik Sarkar, Birendra
Kumar Roy.
College of Veterinary Science, Ranchi, India
ABSTRACT
Sarkar
K, Kumar Roy B., Effect of paracetamol induced liver pathology on disposition of
gatifloxacin in turkeys. Onl
J Vet Res., 28 (9): 530-536, 2024. We determined disposition of gatifloxacin
after oral administration of 20mg/kg gatifloxacin in six
3-4kg, 1-1.5 year control
turkeys and 6 with paracetamol induced liver damage. Peak plasma levels at 2h
were 5.3 + 0.3ug/ml in controls and 5.9 + 0.3ug/ml in those with
liver damage (P > 0.05). However, compared with controls, plasma elimination
rates and clearances were 24-40% lower (P < 0.01) and half-lives 45%, AUC
24%, retention 38%^ and volume of distribution 21% higher (P < 0.01).
Results suggest that 12.52 mg/kg oral gatifloxacin could
be administered at 88h interval in turkeys with liver damage.
Key words:
Disposition kinetics, gatifloxacin, turkeys, hepatopathy, oral.